Post-surgically, the patient had regular echocardiographic follow-ups. He was asymptomatic and tolerated exercise well. Beginning in 2007, the homograft showed signs of moderate aortic valve regurgitation. In August 2014, the patient started complaining of a decreased general status combined with recurrent fever attacks, diffuse myalgia, intermittent headaches and paraesthesia of the face. The consequent echocardiography revealed severe aortic regurgitation (ejection fraction 40%, aortic valve V
max 458.7 cm/s, maximum pressure gradient (PG) 84.2 mm Hg, mean PG 53.5 mm Hg) with adhering vegetations on the aortic valve (
fig. 2). Blood samples were positive for gram-positive streptococci. Antibiotic treatment was initiated for 6 weeks. However, the clinical course deteriorated, with dyspnoea, orthopnoea and peripheral oedema, suggesting the need for an advanced re-operation with valve replacement. Preoperative computed tomography (CT) (
fig. 3) exposed a calcified and extensively destroyed homograft with additional calcification of the proximal left anterior ddescending artery adjacent to the Cabrol anastomosis. Thus, the decision within the heart team was to implant a sutureless, rapidly deployable and self-expandable valve rather than a conventional prosthetic valve (1) to avoid potentially impossible needle-piercing of diseased tissue, (2) to avoid reimplantation of the Cabrol anastomosis, and (3) to reduce the risk of neurological complications due to the calcification and extensive destruction of the homograft.