1 ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA. 2002;288(23):2981–97. doi:http://dx.doi.org/10.1001/jama.288.23.2981.
2 Cushman WC, Davis BR, Pressel SL, Cutler JA, Einhorn PT, Ford CE, et al.; ALLHAT Collaborative Research Group. Mortality and morbidity during and after the antihypertensive and lipid-lowering treatment to prevent heart attack trial. J Clin Hypertens (Greenwich). 2012;14(1):20–31. doi:http://dx.doi.org/10.1111/j.1751-7176.2011.00568.x.
3 James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA. 2014;311(5):507–20. doi:http://dx.doi.org/10.1001/jama.2013.284427.
4 Dasgupta K, Quinn RR, Zarnke KB, Rabi DM, Ravani P, Daskalopoulou SS, et al.; Canadian Hypertension Education Program. The 2014 Canadian Hypertension Education Program recommendations for blood pressure measurement, diagnosis, assessment of risk, prevention, and treatment of hypertension. Can J Cardiol. 2014;30(5):485–501. doi:http://dx.doi.org/10.1016/j.cjca.2014.02.002.
5 Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Böhm M, et al. 2013 ESH/ESC guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J. 2013;34(28):
2159–219. doi:http://dx.doi.org/10.1093/eurheartj/eht151.
6 Carter BL, Ernst ME, Cohen JD. Hydrochlorothiazide versus chlorthalidone: evidence supporting their interchangeability. Hypertension. 2004;43(1):4–9. doi:http://dx.doi.org/10.1161/01.HYP.0000103632.19915.0E.
7 Duarte JD, Cooper-DeHoff RM. Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics. Expert Rev Cardiovasc Ther. 2010;8(6):793–802.
doi:http://dx.doi.org/10.1586/erc.10.27.
8 Colas B, Slama M, Collin T, Safar M, Andrejak M. Mechanisms of methyclothiazide-induced inhibition of contractile responses in rat aorta. Eur J Pharmacol. 2000;408(1):63–7. doi:http://dx.doi.org/10.1016/S0014-2999(00)00704-4.
9 Zhu Z, Zhu S, Liu D, Cao T, Wang L, Tepel M. Thiazide-like diuretics attenuate agonist-induced vasoconstriction by calcium desensitization linked to Rho kinase. Hypertension. 2005;45(2):233–9. doi:http://dx.doi.org/10.1161/01.HYP.0000152701.97426.5f.
10 Pickkers P, Hughes AD, Russel FG, Thien T, Smits P. Thiazide-induced vasodilation in humans is mediated by potassium channel activation. Hypertension. 1998;32(6):1071–6. doi:http://dx.doi.org/10.1161/01.HYP.32.6.1071.
11 Calder JA, Schachter M, Sever PS. Potassium channel opening properties of thiazide diuretics in isolated guinea pig resistance arteries. J Cardiovasc Pharmacol. 1994;24(1):158–64. doi:http://dx.doi.org/10.1097/00005344-199407000-00024.
12 Tobian L. Why do thiazide diuretics lower blood pressure in essential hypertension? Annu Rev Pharmacol. 1967;7(1):399–408. doi:http://dx.doi.org/10.1146/annurev.pa.07.040167.002151.
13 Winer BM. The antihypertensive actions of benzothiadiazines. Circulation. 1961;23(2):211–8. doi:http://dx.doi.org/10.1161/01.CIR.23.2.211.
14 Riess W, Dubach UC, Burckhardt D, Theobald W, Vuillard P, Zimmerli M. Pharmacokinetic studies with chlorthalidone (Hygroton) in man. Eur J Clin Pharmacol. 1977;12(5):375–82. doi:http://dx.doi.org/10.1007/BF00562454.
15 Collste P, Garle M, Rawlins MD, Sjöqvist F. Interindividual differences in chlorthalidone concentration in plasma and red cells of man after single and multiple doses. Eur J Clin Pharmacol. 1976;9(4):319–25. doi:http://dx.doi.org/10.1007/BF00561667.
16 Ford RV. Therapy of edema and hypertension, Comparative clinical effects of chlorothiazide and chlrophthalidolone. Tex State J Med. 1960;56:343–6.
17 Roush GC, Kaur R, Ernst ME. Diuretics: a review and update.
J Cardiovasc Pharmacol Ther. 2014;19(1):5–13. doi:http://dx.doi.org/10.1177/1074248413497257.
18 SHEP Cooperative Research Group. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). JAMA. 1991;265(24):3255–64. doi:http://dx.doi.org/10.1001/jama.1991.03460240051027.
19 National Institute for Health and Care Excellence. Hypertension in adults: diagnosis and management. NICE Guide (CG127) [Internet]. 2011; Available from: http://www.nice.org.uk
20 Flack JM, Sica DA, Bakris G, Brown AL, Ferdinand KC, Grimm RH, Jr, et al.; International Society on Hypertension in Blacks. Management of high blood pressure in Blacks: an update of the International Society on Hypertension in Blacks consensus statement. Hypertension. 2010;56(5):780–800. doi:http://dx.doi.org/10.1161/HYPERTENSIONAHA.110.152892.
21 Calhoun DA, Jones D, Textor S, Goff DC, Murphy TP, Toto RD, et al. Resistant hypertension: diagnosis, evaluation, and treatment. A scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Hypertension. 2008;51(6):1403–19. doi:http://dx.doi.org/10.1161/HYPERTENSIONAHA.108.189141.
22 Mortality after 10 1/2 years for hypertensive participants in the Multiple Risk Factor Intervention Trial. Circulation. 1990;82(5):1616–28. doi:http://dx.doi.org/10.1161/01.CIR.82.5.1616.
23 Dorsch MP, Gillespie BW, Erickson SR, Bleske BE, Weder AB. Chlorthalidone reduces cardiovascular events compared with hydrochlorothiazide: a retrospective cohort analysis. Hypertension. 2011;57(4):689–94. doi:http://dx.doi.org/10.1161/HYPERTENSIONAHA.110.161505.
24 Ernst ME, Neaton JD, Grimm RH, Jr, Collins G, Thomas W, Soliman EZ, et al.; Multiple Risk Factor Intervention Trial Research Group. Long-term effects of chlorthalidone versus hydrochlorothiazide on electrocardiographic left ventricular hypertrophy in the multiple risk factor intervention trial. Hypertension. 2011;58(6):1001–7. doi:http://dx.doi.org/10.1161/HYPERTENSIONAHA.111.181248.
25 Ernst ME, Carter BL, Goerdt CJ, Steffensmeier JJG, Phillips BB, Zimmerman MB, et al. Comparative antihypertensive effects of hydrochlorothiazide and chlorthalidone on ambulatory and office blood pressure. Hypertension. 2006;47(3):352–8. doi:http://dx.doi.org/10.1161/01.HYP.0000203309.07140.d3.
26 Psaty BM, Lumley T, Furberg CD. Meta-analysis of health outcomes of chlorthalidone-based vs nonchlorthalidone-based low-dose diuretic therapies. JAMA. 2004;292(1):43–4. doi:http://dx.doi.org/10.1001/jama.292.1.43-c.
27 Ernst ME, Carter BL, Zheng S, Grimm RH, Jr. Meta-analysis of dose-response characteristics of hydrochlorothiazide and chlorthalidone: effects on systolic blood pressure and potassium. Am J Hypertens. 2010;23(4):440–6. doi:http://dx.doi.org/10.1038/ajh.2010.1.
28 Roush GC, Holford TR, Guddati AK. Chlorthalidone compared with hydrochlorothiazide in reducing cardiovascular events:
systematic review and network meta-analyses. Hypertension. 2012;59(6):1110–7. doi:http://dx.doi.org/10.1161/HYPERTENSIONAHA.112.191106.
29 Dhalla IA, Gomes T, Yao Z, Nagge J, Persaud N, Hellings C, et al. Chlorthalidone versus hydrochlorothiazide for the treatment of hypertension in older adults: a population-based cohort study. Ann Intern Med. 2013;158(6):447–55. doi:http://dx.doi.org/10.7326/0003-4819-158-6-201303190-00004.
30 Pareek AK, Messerli FH, Chandurkar NB, Dharmadhikari SK, Godbole AV, Kshirsagar PP, et al. Efficacy of Low-Dose Chlorthalidone and Hydrochlorothiazide as Assessed by 24-h Ambulatory Blood Pressure Monitoring. J Am Coll Cardiol. 2016;67(4):379–89. doi:http://dx.doi.org/10.1016/j.jacc.2015.10.083.
31 Materson BJ, Oster JR, Michael UF, Bolton SM, Burton ZC, Stambaugh JE, et al. Dose response to chlorthalidone in patients with mild hypertension. Efficacy of a lower dose. Clin Pharmacol Ther. 1978;24(2):192–8. doi:http://dx.doi.org/10.1002/cpt1978242192.
32 Morledge JH, Ettinger B, Aranda J, McBarron F, Barra P, Gorwit J, et al. Isolated systolic hypertension in the elderly. A placebo-controlled, dose-response evaluation of chlorthalidone. J Am Geriatr Soc. 1986;34(3):199–206. doi:http://dx.doi.org/10.1111/j.1532-5415.1986.tb04203.x.
33 Dolan E, Stanton A, Thijs L, Hinedi K, Atkins N, McClory S, et al. Superiority of ambulatory over clinic blood pressure measurement in predicting mortality: the Dublin outcome study. Hypertension. 2005;46(1):156–61. doi:http://dx.doi.org/10.1161/01.HYP.0000170138.56903.7a.
34 Bakris GL, Sica D, White WB, Cushman WC, Weber MA, Handley A, et al. Antihypertensive efficacy of hydrochlorothiazide vs chlorthalidone combined with azilsartan medoxomil. Am J Med. 2012;125:1229.
35 Psaty BM, Smith NL, Siscovick DS, Koepsell TD, Weiss NS, Heckbert SR, et al. Health outcomes associated with antihypertensive therapies used as first-line agents. A systematic review and meta-analysis. JAMA. 1997;277(9):739–45. doi:http://dx.doi.org/10.1001/jama.1997.03540330061036.
36 Kostis JB, Cabrera J, Cheng JQ, Cosgrove NM, Deng Y, Pressel SL, et al. Association between chlorthalidone treatment of systolic hypertension and long-term survival. JAMA. 2011;306(23):2588–93. doi:http://dx.doi.org/10.1001/jama.2011.1821.
37 Cushman WC, Reda DJ, Perry HM, Williams D, Abdellatif M, Materson BJ; Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents. Regional and racial differences in response to antihypertensive medication use in a randomized controlled trial of men with hypertension in the United States. Arch Intern Med. 2000;160(6):825–31. doi:http://dx.doi.org/10.1001/archinte.160.6.825.
38 Multiple Risk Factor Intervention Trial Research Group. Multiple risk factor intervention trial. Risk factor changes and mortality results. JAMA. 1982;248(12):1465–77. doi:http://dx.doi.org/10.1001/jama.1982.03330120023025.
39 Hsieh BP, Pham MX, Froelicher VF. Prognostic value of electrocardiographic criteria for left ventricular hypertrophy. Am Heart J. 2005;150(1):161–7. doi:http://dx.doi.org/10.1016/j.ahj.2004.08.041.
40 Jansen JP, Fleurence R, Devine B, Itzler R, Barrett A, Hawkins N, et al. Interpreting indirect treatment comparisons and network meta-analysis for health-care decision making: report of the ISPOR Task Force on Indirect Treatment Comparisons Good Research Practices: part 1. Value Health. 2011;14(4):417–28. doi:http://dx.doi.org/10.1016/j.jval.2011.04.002.
41 Alfonzo AVM, Isles C, Geddes C, Deighan C. Potassium disorders--clinical spectrum and emergency management. Resuscitation. 2006;70(1):10–25. doi:http://dx.doi.org/10.1016/j.resuscitation.2005.11.002.
42 Degnbol B, Dorph S, Marner T. The effect of different diuretics on elevated blood pressure and serum potassium. Acta Med Scand. 1973;193(5):407–10.
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44 Siegel D, Hulley SB, Black DM, Cheitlin MD, Sebastian A, Seeley DG, et al. Diuretics, serum and intracellular electrolyte levels, and ventricular arrhythmias in hypertensive men. JAMA. 1992;267(8):1083–9. doi:http://dx.doi.org/10.1001/jama.1992.03480080053026.
45 Vaitkevicius H, Turner I, Spalding A, Lockette W. Chloride increases adrenergic receptor-mediated platelet and vascular responses. Am J Hypertens. 2002;15(6):492–8. doi:http://dx.doi.org/10.1016/S0895-7061(02)02276-8.
46 Woodman R, Brown C, Lockette W. Chlorthalidone decreases platelet aggregation and vascular permeability and promotes angiogenesis. Hypertension. 2010;56(3):463–70. doi:http://dx.doi.org/10.1161/HYPERTENSIONAHA.110.154476.
47 Carlsen JE, Køber L, Torp-Pedersen C, Johansen P. Relation between dose of bendrofluazide, antihypertensive effect, and adverse biochemical effects. BMJ. 1990;300(6730):975–8. doi:http://dx.doi.org/10.1136/bmj.300.6730.975.
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49 Lamers H, Joos S, Goetz K, Hermann K, Szecsenyi J, Kühlein T. Diuretics for hypertension-reasons for a contradiction in primary care prescribing behavior: a qualitative study. J Clin Hypertens (Greenwich). 2012;14(10):680–5. doi:http://dx.doi.org/10.1111/j.1751-7176.2012.00680.x.
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1 ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA. 2002;288(23):2981–97. doi:http://dx.doi.org/10.1001/jama.288.23.2981.
2 Cushman WC, Davis BR, Pressel SL, Cutler JA, Einhorn PT, Ford CE, et al.; ALLHAT Collaborative Research Group. Mortality and morbidity during and after the antihypertensive and lipid-lowering treatment to prevent heart attack trial. J Clin Hypertens (Greenwich). 2012;14(1):20–31. doi:http://dx.doi.org/10.1111/j.1751-7176.2011.00568.x.
3 James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA. 2014;311(5):507–20. doi:http://dx.doi.org/10.1001/jama.2013.284427.
4 Dasgupta K, Quinn RR, Zarnke KB, Rabi DM, Ravani P, Daskalopoulou SS, et al.; Canadian Hypertension Education Program. The 2014 Canadian Hypertension Education Program recommendations for blood pressure measurement, diagnosis, assessment of risk, prevention, and treatment of hypertension. Can J Cardiol. 2014;30(5):485–501. doi:http://dx.doi.org/10.1016/j.cjca.2014.02.002.
5 Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Böhm M, et al. 2013 ESH/ESC guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J. 2013;34(28):
2159–219. doi:http://dx.doi.org/10.1093/eurheartj/eht151.
6 Carter BL, Ernst ME, Cohen JD. Hydrochlorothiazide versus chlorthalidone: evidence supporting their interchangeability. Hypertension. 2004;43(1):4–9. doi:http://dx.doi.org/10.1161/01.HYP.0000103632.19915.0E.
7 Duarte JD, Cooper-DeHoff RM. Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics. Expert Rev Cardiovasc Ther. 2010;8(6):793–802.
doi:http://dx.doi.org/10.1586/erc.10.27.
8 Colas B, Slama M, Collin T, Safar M, Andrejak M. Mechanisms of methyclothiazide-induced inhibition of contractile responses in rat aorta. Eur J Pharmacol. 2000;408(1):63–7. doi:http://dx.doi.org/10.1016/S0014-2999(00)00704-4.
9 Zhu Z, Zhu S, Liu D, Cao T, Wang L, Tepel M. Thiazide-like diuretics attenuate agonist-induced vasoconstriction by calcium desensitization linked to Rho kinase. Hypertension. 2005;45(2):233–9. doi:http://dx.doi.org/10.1161/01.HYP.0000152701.97426.5f.
10 Pickkers P, Hughes AD, Russel FG, Thien T, Smits P. Thiazide-induced vasodilation in humans is mediated by potassium channel activation. Hypertension. 1998;32(6):1071–6. doi:http://dx.doi.org/10.1161/01.HYP.32.6.1071.
11 Calder JA, Schachter M, Sever PS. Potassium channel opening properties of thiazide diuretics in isolated guinea pig resistance arteries. J Cardiovasc Pharmacol. 1994;24(1):158–64. doi:http://dx.doi.org/10.1097/00005344-199407000-00024.
12 Tobian L. Why do thiazide diuretics lower blood pressure in essential hypertension? Annu Rev Pharmacol. 1967;7(1):399–408. doi:http://dx.doi.org/10.1146/annurev.pa.07.040167.002151.
13 Winer BM. The antihypertensive actions of benzothiadiazines. Circulation. 1961;23(2):211–8. doi:http://dx.doi.org/10.1161/01.CIR.23.2.211.
14 Riess W, Dubach UC, Burckhardt D, Theobald W, Vuillard P, Zimmerli M. Pharmacokinetic studies with chlorthalidone (Hygroton) in man. Eur J Clin Pharmacol. 1977;12(5):375–82. doi:http://dx.doi.org/10.1007/BF00562454.
15 Collste P, Garle M, Rawlins MD, Sjöqvist F. Interindividual differences in chlorthalidone concentration in plasma and red cells of man after single and multiple doses. Eur J Clin Pharmacol. 1976;9(4):319–25. doi:http://dx.doi.org/10.1007/BF00561667.
16 Ford RV. Therapy of edema and hypertension, Comparative clinical effects of chlorothiazide and chlrophthalidolone. Tex State J Med. 1960;56:343–6.
17 Roush GC, Kaur R, Ernst ME. Diuretics: a review and update.
J Cardiovasc Pharmacol Ther. 2014;19(1):5–13. doi:http://dx.doi.org/10.1177/1074248413497257.
18 SHEP Cooperative Research Group. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). JAMA. 1991;265(24):3255–64. doi:http://dx.doi.org/10.1001/jama.1991.03460240051027.
19 National Institute for Health and Care Excellence. Hypertension in adults: diagnosis and management. NICE Guide (CG127) [Internet]. 2011; Available from: http://www.nice.org.uk
20 Flack JM, Sica DA, Bakris G, Brown AL, Ferdinand KC, Grimm RH, Jr, et al.; International Society on Hypertension in Blacks. Management of high blood pressure in Blacks: an update of the International Society on Hypertension in Blacks consensus statement. Hypertension. 2010;56(5):780–800. doi:http://dx.doi.org/10.1161/HYPERTENSIONAHA.110.152892.
21 Calhoun DA, Jones D, Textor S, Goff DC, Murphy TP, Toto RD, et al. Resistant hypertension: diagnosis, evaluation, and treatment. A scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Hypertension. 2008;51(6):1403–19. doi:http://dx.doi.org/10.1161/HYPERTENSIONAHA.108.189141.
22 Mortality after 10 1/2 years for hypertensive participants in the Multiple Risk Factor Intervention Trial. Circulation. 1990;82(5):1616–28. doi:http://dx.doi.org/10.1161/01.CIR.82.5.1616.
23 Dorsch MP, Gillespie BW, Erickson SR, Bleske BE, Weder AB. Chlorthalidone reduces cardiovascular events compared with hydrochlorothiazide: a retrospective cohort analysis. Hypertension. 2011;57(4):689–94. doi:http://dx.doi.org/10.1161/HYPERTENSIONAHA.110.161505.
24 Ernst ME, Neaton JD, Grimm RH, Jr, Collins G, Thomas W, Soliman EZ, et al.; Multiple Risk Factor Intervention Trial Research Group. Long-term effects of chlorthalidone versus hydrochlorothiazide on electrocardiographic left ventricular hypertrophy in the multiple risk factor intervention trial. Hypertension. 2011;58(6):1001–7. doi:http://dx.doi.org/10.1161/HYPERTENSIONAHA.111.181248.
25 Ernst ME, Carter BL, Goerdt CJ, Steffensmeier JJG, Phillips BB, Zimmerman MB, et al. Comparative antihypertensive effects of hydrochlorothiazide and chlorthalidone on ambulatory and office blood pressure. Hypertension. 2006;47(3):352–8. doi:http://dx.doi.org/10.1161/01.HYP.0000203309.07140.d3.
26 Psaty BM, Lumley T, Furberg CD. Meta-analysis of health outcomes of chlorthalidone-based vs nonchlorthalidone-based low-dose diuretic therapies. JAMA. 2004;292(1):43–4. doi:http://dx.doi.org/10.1001/jama.292.1.43-c.
27 Ernst ME, Carter BL, Zheng S, Grimm RH, Jr. Meta-analysis of dose-response characteristics of hydrochlorothiazide and chlorthalidone: effects on systolic blood pressure and potassium. Am J Hypertens. 2010;23(4):440–6. doi:http://dx.doi.org/10.1038/ajh.2010.1.
28 Roush GC, Holford TR, Guddati AK. Chlorthalidone compared with hydrochlorothiazide in reducing cardiovascular events:
systematic review and network meta-analyses. Hypertension. 2012;59(6):1110–7. doi:http://dx.doi.org/10.1161/HYPERTENSIONAHA.112.191106.
29 Dhalla IA, Gomes T, Yao Z, Nagge J, Persaud N, Hellings C, et al. Chlorthalidone versus hydrochlorothiazide for the treatment of hypertension in older adults: a population-based cohort study. Ann Intern Med. 2013;158(6):447–55. doi:http://dx.doi.org/10.7326/0003-4819-158-6-201303190-00004.
30 Pareek AK, Messerli FH, Chandurkar NB, Dharmadhikari SK, Godbole AV, Kshirsagar PP, et al. Efficacy of Low-Dose Chlorthalidone and Hydrochlorothiazide as Assessed by 24-h Ambulatory Blood Pressure Monitoring. J Am Coll Cardiol. 2016;67(4):379–89. doi:http://dx.doi.org/10.1016/j.jacc.2015.10.083.
31 Materson BJ, Oster JR, Michael UF, Bolton SM, Burton ZC, Stambaugh JE, et al. Dose response to chlorthalidone in patients with mild hypertension. Efficacy of a lower dose. Clin Pharmacol Ther. 1978;24(2):192–8. doi:http://dx.doi.org/10.1002/cpt1978242192.
32 Morledge JH, Ettinger B, Aranda J, McBarron F, Barra P, Gorwit J, et al. Isolated systolic hypertension in the elderly. A placebo-controlled, dose-response evaluation of chlorthalidone. J Am Geriatr Soc. 1986;34(3):199–206. doi:http://dx.doi.org/10.1111/j.1532-5415.1986.tb04203.x.
33 Dolan E, Stanton A, Thijs L, Hinedi K, Atkins N, McClory S, et al. Superiority of ambulatory over clinic blood pressure measurement in predicting mortality: the Dublin outcome study. Hypertension. 2005;46(1):156–61. doi:http://dx.doi.org/10.1161/01.HYP.0000170138.56903.7a.
34 Bakris GL, Sica D, White WB, Cushman WC, Weber MA, Handley A, et al. Antihypertensive efficacy of hydrochlorothiazide vs chlorthalidone combined with azilsartan medoxomil. Am J Med. 2012;125:1229.
35 Psaty BM, Smith NL, Siscovick DS, Koepsell TD, Weiss NS, Heckbert SR, et al. Health outcomes associated with antihypertensive therapies used as first-line agents. A systematic review and meta-analysis. JAMA. 1997;277(9):739–45. doi:http://dx.doi.org/10.1001/jama.1997.03540330061036.
36 Kostis JB, Cabrera J, Cheng JQ, Cosgrove NM, Deng Y, Pressel SL, et al. Association between chlorthalidone treatment of systolic hypertension and long-term survival. JAMA. 2011;306(23):2588–93. doi:http://dx.doi.org/10.1001/jama.2011.1821.
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