Herztod in den Bergen

Epigenetic mechanisms of vascular dysfunction in obesity and type 2 diabetes

A careful assessment of the “epigenetic landscape” in cardiometabolic patients may contribute to the estimation of global cardiovascular risk, thus providing the tools for a personalised therapeutic approach. The present review describes the emerging role of epigenetics in the pathogenesis of cardiovascular complications in obesity and type 2 diabetes.

Arrhythmic mitral valve prolapse

Gender aspects in cardiac imaging

This article reviews existing gender differences in cardiac imaging in terms of extra-cardiac anatomy, cardiac anatomy, myocardium remodelling and cardiac response to injury. It underlines the need for “gender medicine”, where gender differences and female patients’ representation are taken into account in cardiovascular research and clinical trials, as a first step toward tailored therapies and health care.

Very low-dose direct oral anticoagulants combined with platelet inhibitors in coronary artery disease: ready for widespread use?

Very low-dose anticoagulation in the form of rivaroxaban twice daily is a welcoming addition to the current antithrombotic arsenal in high-risk patients with acute coronary syndrome or stable coronary artery disease. Adequate patient selection in line with the entry criteria of the approval trials appears to be critical to avoid excessive bleeding.

Sinus venosus and unroofed coronary sinus defects: two cases diagnosed and treated in adulthood

Interatrial communications are the most frequent congenital heart malformation in adulthood. We report typical examples of sinus venosus and unroofed coronary sinus defects associated with anomalous pulmonary venous return.

Surgical treatment of severe aortic valve stenosis with concomitant Fabry disease

Aggressive surgical management of patients with severe aortic stenosis and concomitant Fabry disease should be the treatment of choice, even during enzyme replacement therapy.

Paul M. Vanhoutte dies in Paris aged 79

Prevention Summit 2019 Berlin: Das Zurich Heart House reicht über die Grenze hinaus

Forschungspreis 2019 der Schweizerischen Herzstiftung geht an Dr. Raphael Twerenbold